Journal club of the week: functionality of nanomaterials regarding their toxicity

 
Speaker: PhDs Armin Salek
Date: In 5/23/2016
Topic: functionality of nanomaterials regarding their toxicity

In 5/23/2016 meeting of the journal club, the functionality of nanomaterials regarding their toxicity was presented by the PhDs Armin Salek.  The toxicity of nanoparticles (NP) depends on its physical, chemical interactions with gases, liquids and other nanoparticles surrounding them. This can be studied using molecular simulations. The specific and quantitative knowledge obtained from theory and simulation can help build predictive models and algorithm for assessing the likelihood of toxicity in various natural environments. Several studies conclude that the response to nanoparticles is too diverse. For instance, dogs and pigs have a higher immune-response to nanoparticles. Unbiased MD simulations show that the fullerenes easily pass through the lipid head group, to further diffuse slowly within the bilayer region. Fullerene and fullerene aggregate are kinetically and thermodynamically favored to locate near the center of the membrane. Titanium dioxide (TiO2) a powerful photocatalyst in three forms of rutile, anatase and brookite is an example. Anatase form has raised concerns on toxicity. The toxicity of the anatase NP is expected to increase with  temperature and reduction in size.