Journal club of the week: The physiological role of P-gp

Speaker: Mahshid Hodjat the postdoc fellow
Date: 11th of April, 2016
Topic: The physiological role of P-gp

In the Recent journal meeting on 11th of April, 2016, Ms. Mahshid Hodjat the postdoc fellow introduced the participants’ P-glycoprotein. She talked that P-glycoprotein is the most well known member of a family of transmembrane proteins called the ATP-binding cassette family (ABC), also referred to as Multidrug Resistance Protein (MDR1), CD243 and by its gene name, ABCB1. The physiological role of P-gp is to protect susceptible organs from toxic xenobiotics, the secretion of metabolites and xenobiotics into bile, urine, and the lumen of the gastrointestinal tract. Pgp can interact with a vast array of molecules of diverse structure including natural products, chemotherapeutic drugs, steroids, linear and cyclic peptides, fluorescent dyes and ionophores. Expression of P-glycoprotein can have important effects on drug absorption, distribution and elimination. She also described that compounds known as modulators can block the drug-efflux activity of Pgp, and may have important clinical applications in cancer therapy and drug delivery to the brain. Central nervous system depression, undertreated HIV infection and transplant rejection are possible outcomes of modulator interactions. Knowledge of these potential interactions in at-risk patient groups can help ensure the provision of safe and effective treatment. Prof. Dr. Abdollahi put light on the whole presentation and gave a brief summary. At the end all participants asked their valuable questions and he answered all the questions.