Journal Club of the week: Alzheimer’s disease

Journal Club of the week: Alzheimer’s disease (AD)

 Speaker:Ms Leili Jalili, PhDs 

 Date: January 25, 2016

Topic: Alzheimer’s disease (AD)


In the January 25, 2016 journal meeting Ms Leili Jalili the PhDs introduced the participants to Alzheimer’s disease (AD) which accounts for 60% to 70% of cases of dementia. She said that the cause of AD is poorly understood. About 70% of the risk is believed to be genetic with many genes usually involved. Other risk factors include a history of head injuries, depression and hypertension. She told about the treatment protocol for AD. No treatments stop or reverse its progression, though some may temporarily improve symptoms. Affected people increasingly rely on others for assistance, often placing a burden on the caregiver; the pressures can include social, psychological, physical, and economic elements. Exercise programs are beneficial with respect to activities of daily living and can potentially improve outcomes. Treatment of behavioral problems or psychosis due to dementia with anti-psychotics are common but not usually recommended due to their often being little benefit and an increased risk of early death. She also talked how different hypothesis has been proposed for AD like the genetic heritability of AD, cholinergic hypothesis, amyloid hypothesis, tau hypothesis and others. In the last Ms L Jalili discussed that proper medication, lifestyle and diet can lower the risk of AD. She told that five medications are currently used to treat the cognitive problems of AD: four are acetyl cholinesterase inhibitors (tacrine, rivastigmine, galatamine and donepezil) and the other (memantine) is an NMDA receptor antagonist. The benefit from their use is small. No medication has been clearly shown to delay or halt the progression of the disease. At the end all participants asked their valuable questions and she answered all the questions and Prof Abdollahi summarized the whole story.