The PSRC of the Tehran University of Medical Sciences

The PSRC of the Tehran University of Medical Sciences (TUMS) was established in mid 2003. The PSRC tries to spread interest in research among students, to recruit and support researchers at all academic levels, to conduct both fundamental and applied (practical) researches in different fields of pharmaceutical sciences, and to promote research methods and training. The center's present activity is mainly focused on research in different ...

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Latest News

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برگزاری جلسه کمیته اخلاق مرکز در بهمن ماه 1395

{p} جلسه کمیته اخلاق مرکز روز شنبه 16 بهمن ماه 95 در محل کلاس تخصصی منفی یک برگزار شد. در این جلسه طرح ها و پایان نامه های ارسال شده مورد بررسی قرار گرفتند و نیز علل تاخیر در تصویب یا رد برخی از موارد ارسالی بررسی، و راهکارهای مناسب در مورد هر یک ارائه شد. با توجه به وجود برخی اشکالات مشترک در پایان نامه ها و طرح ها پیشنهاد شد کارگاه اخلاق در پزشکی با رویکرد اختصاصی به علوم دارویی و پروژه های معمول در دانشکده داروسازی با امتیاز فرهنگی برگزار شود تا با اطلاع رسانی صحیح به مجریان و اساتید محترم از اشکالات و موارد غیر ضروری کاسته شود و روند تصویب طرح ها نیز تسهیل گردد. تذکر به رعایت اخلاق و عدم ارائه همزمان طرح به چند کمیته اخلاق و نیز بایگانی طرح در صورت عدم توجه مجریان محترم در پاسخگویی به سوالات البته پس از سه اخطار از مصوبات این کمیته بود. {/p}

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برنامه جذب دستیار پژوهش (پزشک/داروساز/دندانپزشک عمومی مشمول طرح نیروی انسانی)

{p} Created on Saturday, 29 April 2017 12:09 لطفا برای مشاهده اطلاعات کامل به نشانی http://rap.hbi.ir/ مراجعه فرمایید. {/p}

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جلسه شورای علمی مرکز- فروردین 1396

{p} جلسه شورای علمی مرکز راس ساعت 12 روز یکشنبه 1396/2/3 با حضور اعضای محترم این شورا تشکیل شد. در این جلسه علاوه بر بررسی و تصویب 7 طرح پژوهشی و یک پایان نامه دکترای تخصصی، مسائل مختلف مورد بررسی و بحث قرار گرفت. {/p}

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ثبت نام تور بازدید از مرکز رشد فرآورده های دارویی

{p} بدین وسیله به استحضار می رساند که دفتر همکاری دانشگاه، صنعت و جامعه علوم پزشکی تهران با هدف آشناسازی و آگاهی محققین، دانشجویان، اساتید و علاقمندان به علوم فناوریهای نوین پزشکی در نظر دارد برنامه بازدیدی را در تاریخ 23/02/96(روز شنبه) از شرکتهای دانش بنیان مستقر در مرکز رشد فرآورده های دارویی به انجام رساند، لذا خواهشمند است علاقمندان جهت شرکت در این برنامه علمی از طریق شماره تلفن های 88392549- 09365558512(خانم سلطانی) و حداکثر تا یک هفته قبل از زمان بازید نسبت به ثبت نام اقدام نمایند. {/p}

Journal Clubs

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    Anti-Tumor Vaccines

    Journal Club of the Week: Anti-Tumor Vaccines? On 15th May 2017, journal club meeting, the topic “Anti-Tumor Vaccines?” was discussed. In general, there are two types of cancer vaccines. The first is the prophylactic vaccine, which just like any kind of conventional vaccine is given to a person before cancer emerges to protect a person against further cancer. This type of cancer vaccines was successful to be launched to the market and there are some available products in this field, including Gardasil and Cervix against cervical cancer and HBS Ag Vaccine against hepatocellular carcinoma. If the researchers to design appropriate vaccines against H. pylori results in success, we can be hopeful to protect people against stomach cancer by vaccination in the future. The cancer prophylactic vaccines, in fact, protect the body against a specific cause of cancer not against cancer which emerged due to other reasons. In the case of cervical cancer, a prophylactic vaccine can immunize the body against papillomavirus infection, which if left untreated can cause subsequent cancer. About the hepatocellular carcinoma, the scenario is the same. The second type of cancer vaccine is therapeutic vaccines, which are given to patients who have already been diagnosed with cancer. Tumor cell, Peptides, Anti-idiotypic vaccines, DNA Vaccines and dendritic cell-based vaccine are different approaches in this category. There are some clinically available examples of cancer therapeutic vaccines, including OncoVax, Sipuleucel-T, and CimaVaxEGF. Although cancer vaccines are new in the treatment setting of cancer, maybe they will be the future of cancer treatments.

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    Toxicity of perfluorooctanoic acid: Implications for health risks

    Journal Club of the Week: Toxicity of perfluorooctanoic acid: Implications for health risks On 8th May 2017, journal club meeting, the topic “Toxicity of perfluorooctanoic acid: Implications for health risks.” was discussed. As an emerging persistent organic pollutant (POP), perfluorooctanoate (PFOA) is one of the most abundant perfluorinated compounds (PFCs) in the environment. This molecular mechanisms and signaling pathways of PFOA-induced toxicity in animals and humans as well as their implications for health risks in humans were described. Traditional PFOA-induced signal pathways such as peroxisome proliferating receptor alpha (PPARα), constitutive androstane receptor (CAR), farnesoid X receptor (FXR), and pregnane-X receptor (PXR) may not be important for PFOA-induced health effects on humans. Instead, pathways, including p53/mitochondrial, nuclear lipid hyperaccumulation, phosphatidylinositol 3-kinase-serine/threonine protein kinase (PI3K-AKT), and tumor necrosis factor-α/nuclear factor κB (TNF-α/NF-κB) play roles for PFOA-induced health risks in humans. Both in vivo and in vitro studies are needed to better understand the PFOA-induced toxicity mechanisms as well as the associated health risk in humans.

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    The therapeutic actions of melatonin: A brief look at its possible protective role in AlP poisonin

    Journal Club of the WeeK: The therapeutic actions of melatonin: A brief look at its possible protective role in AlP poisoning On 1st May 2017, journal club meeting, the topic “The therapeutic actions of melatonin: A brief look at its possible protective role in AlP poisoning.” was discussed. Melatonin is a phylogenetically well-preserved molecule with diverse physiological functions. In addition to its well-known regulatory control of the sleep/wake cycle, as well as circadian rhythms generally, melatonin is involved in immunomodulation, hematopoiesis, and antioxidative processes. Recent human and animal studies have now shown that melatonin also has important oncostatic properties. Both at physiological and pharmacological doses, melatonin exerts growth inhibitory effects on some cancer cells.

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    Analytical methods for human biomonitoring of pesticides

    Journal Club of the Week: Analytical methods for human biomonitoring of pesticides On 24th of April 2017, journal club meeting, the topic “Analytical methods for human biomonitoring of pesticides” was discussed. The biomonitoring of commonly used pesticides is an important tool for evaluating human exposure to these toxic chemicals. Current approaches and recent advances in the analytical methods for determining the biomarkers of exposure to pesticides in the most commonly used specimens, such as blood, urine, and breast milk, and in emerging non-invasive matrices such as hair and meconium was described. The main applications for sample treatment and the instrumental techniques currently used to determine the most relevant pesticide biomarker were critically discussed.

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    Reaxys and its applications

    Journal Club of the Week: Reaxys and its applications On 17th of April 2017, journal club meeting, the topic “Reaxys and its applications” was discussed. Reaxys is a search engine that helps researchers, students, industry personnel’s and others working in chemistry and related areas retrieve relevant chemical literature, experimental protocols, patent information and standard compound properties. There are various filter options to specify properties, limit the items and compare the search to fit a category of the particular substance of interest. Besides, the reaxys is a subscriber website that provides service to a wide range of customers. Reaxys medicinal chemistry (RMC) is a new feature comprising search options to access information related to biological activity, drug targets, various drug data including pharmacological and toxicology details drugs and other important molecules at different stages of drug development. On the other hand, reaxys natural products (RNP) are an alternative search tool to RMC that is designed to obtain data on properties of isolated natural products and their derivatives.

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    Toxicoepigenetics; An emerging field of research in toxicology

    Journal Club of the Week: Toxicoepigenetics; An emerging field of research in toxicology In the 10th April 2017, journal club meeting, the topic of Toxicoepigenetics was discussed as an emerging field of research in toxicology. Different mechanisms at the cellular and molecular level, the limitations and future perspective, and relation with current growth of diseases were explained.