The PSRC of the Tehran University of Medical Sciences

The PSRC of the Tehran University of Medical Sciences (TUMS) was established in mid 2003. The PSRC tries to spread interest in research among students, to recruit and support researchers at all academic levels, to conduct both fundamental and applied (practical) researches in different fields of pharmaceutical sciences, and to promote research methods and training. The center's present activity is mainly focused on research in different fields ...

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Pre-defence meeting of Kamal Niaz, PSRC international Student

Kamal Niaz, the PhD student of Pharmacology and Toxicology under supervision of Prof Mohammad Abdollahi presented his thesis predefense meeting on Saturday 19th August 2017, that was successfully approved by the referees.



APAMT Scientific Congress 2017

Translation of Toxicology Evidence into practice
7-10th November


سومین کنگره سالانه انکولوژی

کنگره سالانه انکولوژی به میزبانی دانشکده علوم پزشکی و خدمات بهداشتی درمانی گراش- استان فارس در روزهای 9 و 10 آذرماه سال 1396 برگزار می شود.



کارگاه آشنایی با رویکرد OMICS در اپیدمیولوژی

احتراماً به استحضار میرساند کارگاه "آشنایی با رویکرد OMICS در اپیدمیولوژی" طی روزهای 16 الی18 مردادماه 1396 از سوی پژوهشگاه علوم غدد و متابولیسم دانشگاه علوم پزشکی تهران (مرکز تحقیقات استئوپروز) برگزار می گردد.

Journal Clubs

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    Gelatin Zymography & its Implications in Cardiac Remodeling

    On 22nd May 2017, journal club meeting, the topic “Gelatin Zymography & its Implications in Cardiac Remodeling” was discussed.The rising global burden and irreversibility of heart failure necessitate the need of cardiac interventions to decrease post-myocardial infarction (MI) morbidity and mortality. Post – MI genomic, molecular, cellular & interstitial changes are manifested clinically as changes in the size, shape, & function of the heart after cardiac injury - phenomena termed as Cardiac Remodeling (CR). Cardiac fibroblasts and the highly invasive myofibroblasts are the keys players involved in the process of CR. Matrix metalloproteinase (MMPs) system is the dominant proteolytic system involved in the degradation of the extracellular matrix in the heart. The increased activity MMP-2 and -9 is temporally associated with cardiac rupture. Moreover, targeted deletion of MMP-2 and -9 has been shown to improve post-MI survival by hindering macrophage infiltration and reducing LV dilatation and dysfunction. Gelatin zymography is a simple yet powerful method to detect proteolytic enzymes capable of degrading gelatin (MMP-2 and MMP-9) from various biological sources. This polyacrylamide gel electrophoresis-based method can provide a reliable assessment of the type of gelatinase, relative amount, and activation status (latent, compared with active enzyme forms) in cultured cells, tissues, and biological fluids. There are numerous advantages of this low-cost and highly sensitive technique, but the fact that it requires good optimization and troubleshooting can also not be ignored.

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    Anti-Tumor Vaccines

    On 15th May 2017, journal club meeting, the topic “Anti-Tumor Vaccines?” was discussed. In general, there are two types of cancer vaccines. The first is the prophylactic vaccine, which just like any kind of conventional vaccine is given to a person before cancer emerges to protect a person against further cancer. This type of cancer vaccines was successful to be launched to the market and there are some available products in this field, including Gardasil and Cervix against cervical cancer and HBS Ag Vaccine against hepatocellular carcinoma. If the researchers to design appropriate vaccines against H. pylori results in success, we can be hopeful to protect people against stomach cancer by vaccination in the future. The cancer prophylactic vaccines, in fact, protect the body against a specific cause of cancer not against cancer which emerged due to other reasons. In the case of cervical cancer, a prophylactic vaccine can immunize the body against papillomavirus infection, which if left untreated can cause subsequent cancer. About the hepatocellular carcinoma, the scenario is the same. The second type of cancer vaccine is therapeutic vaccines, which are given to patients who have already been diagnosed with cancer. Tumor cell, Peptides, Anti-idiotypic vaccines, DNA Vaccines and dendritic cell-based vaccine are different approaches in this category. There are some clinically available examples of cancer therapeutic vaccines, including OncoVax, Sipuleucel-T, and CimaVaxEGF. Although cancer vaccines are new in the treatment setting of cancer, maybe they will be the future of cancer treatments.

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    Toxicity of perfluorooctanoic acid: Implications for health risks

    On 8th May 2017, journal club meeting, the topic “Toxicity of perfluorooctanoic acid: Implications for health risks.” was discussed. As an emerging persistent organic pollutant (POP), perfluorooctanoate (PFOA) is one of the most abundant perfluorinated compounds (PFCs) in the environment. This molecular mechanisms and signaling pathways of PFOA-induced toxicity in animals and humans as well as their implications for health risks in humans were described. Traditional PFOA-induced signal pathways such as peroxisome proliferating receptor alpha (PPARα), constitutive androstane receptor (CAR), farnesoid X receptor (FXR), and pregnane-X receptor (PXR) may not be important for PFOA-induced health effects on humans. Instead, pathways, including p53/mitochondrial, nuclear lipid hyperaccumulation, phosphatidylinositol 3-kinase-serine/threonine protein kinase (PI3K-AKT), and tumor necrosis factor-α/nuclear factor κB (TNF-α/NF-κB) play roles for PFOA-induced health risks in humans. Both in vivo and in vitro studies are needed to better understand the PFOA-induced toxicity mechanisms as well as the associated health risk in humans.

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    The therapeutic actions of melatonin: A brief look at its possible protective role in AlP poisonin

    On 1st May 2017, journal club meeting, the topic “The therapeutic actions of melatonin: A brief look at its possible protective role in AlP poisoning.” was discussed. Melatonin is a phylogenetically well-preserved molecule with diverse physiological functions. In addition to its well-known regulatory control of the sleep/wake cycle, as well as circadian rhythms generally, melatonin is involved in immunomodulation, hematopoiesis, and antioxidative processes. Recent human and animal studies have now shown that melatonin also has important oncostatic properties. Both at physiological and pharmacological doses, melatonin exerts growth inhibitory effects on some cancer cells.