The PSRC of the Tehran University of Medical Sciences

The PSRC of the Tehran University of Medical Sciences (TUMS) was established in mid 2003. The PSRC tries to spread interest in research among students, to recruit and support researchers at all academic levels, to conduct both fundamental and applied (practical) researches in different fields of pharmaceutical sciences, and to promote research methods and training. The center's present activity is mainly focused on research in different fields ...

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نگارش فصل 15 از کتاب Probiotics, Prebiotics, and Synbiotics; Bioactive Foods in Health Promotion توسط اعضای هیات علمی دانشگاه علوم پزشکی تهران

در کتاب Probiotics, Prebiotics, and Synbiotics; Bioactive Foods in Health Promotion از انتشارات Elsevier ، جمعی از اعضای هیات علمی مرکز تحقیقات علوم دارویی، دانشکده داروسازی، پردیس بین الملل، و انستیتو گیاهان دارویی، فصلی را با عنوان Safety of Probiotic Bacteria  به رشته تحریر درآوردند.

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Top researcher award of the year for Fazlullah Khan- PSRC International Student

Fazlullah Khan, International Student of PSRC got "Top researcher award of the year" among international students in Tehran University of Medical Sciences.

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انتشار فصلی از کتاب Toxicology in the Middle Ages and Renaissance توسط اعضای هیات علمی دانشگاه علوم پزشکی تهران

در کتاب Toxicology in the Middle Ages and Renaissance که از آخرین انتشارات Elsevier در سال 2017 امریکا می باشد، جمعی از اعضا هیات علمی مرکز تحقیقات علوم دارویی، دانشکده داروسازی، و دانشکده طب سنتی دانشگاه علوم پزشکی تهران به همراهی دانشگاه سلطان قابوس عمان، فصلی را با عنوان The Golden Age of Medieval Islamic Toxicology به رشته تحریر درآوردند.

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Journal Clubs

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    In vivo Imaging of Biomaterial-Associated Infection

    On 18th September 2017, in journal club meeting, the topic “In vivo Imaging of Biomaterial-Associated Infection.” was discussed. The speaker highlighted the current state of Bioluminescence and Fluorescent Imaging technologies (BLI and FLI) as applied to Biomaterial-Associated Infections (BAI). BLI provides the opportunity to observe the in vivo course of BAI in small animals without the need to sacrifice animals at different time points after the onset of infection. BLI is highly dependent on the bacterial cell metabolism which makes BLI a strong reporter of viable bacterial presence. The sensitivity and spatial resolution of both imaging tools are, however, dependent on the imaging system used and the tissue characteristics, which makes the interpretation of images, in terms of the location and shape of the illuminating source, difficult. It is anticipated that bio-optical imaging will become an indispensable technology for the in vivo evaluation of antimicrobial coatings.

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    Gelatin Zymography & its Implications in Cardiac Remodeling

    On 22nd May 2017, journal club meeting, the topic “Gelatin Zymography & its Implications in Cardiac Remodeling” was discussed.The rising global burden and irreversibility of heart failure necessitate the need of cardiac interventions to decrease post-myocardial infarction (MI) morbidity and mortality. Post – MI genomic, molecular, cellular & interstitial changes are manifested clinically as changes in the size, shape, & function of the heart after cardiac injury - phenomena termed as Cardiac Remodeling (CR). Cardiac fibroblasts and the highly invasive myofibroblasts are the keys players involved in the process of CR. Matrix metalloproteinase (MMPs) system is the dominant proteolytic system involved in the degradation of the extracellular matrix in the heart. The increased activity MMP-2 and -9 is temporally associated with cardiac rupture. Moreover, targeted deletion of MMP-2 and -9 has been shown to improve post-MI survival by hindering macrophage infiltration and reducing LV dilatation and dysfunction. Gelatin zymography is a simple yet powerful method to detect proteolytic enzymes capable of degrading gelatin (MMP-2 and MMP-9) from various biological sources. This polyacrylamide gel electrophoresis-based method can provide a reliable assessment of the type of gelatinase, relative amount, and activation status (latent, compared with active enzyme forms) in cultured cells, tissues, and biological fluids. There are numerous advantages of this low-cost and highly sensitive technique, but the fact that it requires good optimization and troubleshooting can also not be ignored.

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    Anti-Tumor Vaccines

    On 15th May 2017, journal club meeting, the topic “Anti-Tumor Vaccines?” was discussed. In general, there are two types of cancer vaccines. The first is the prophylactic vaccine, which just like any kind of conventional vaccine is given to a person before cancer emerges to protect a person against further cancer. This type of cancer vaccines was successful to be launched to the market and there are some available products in this field, including Gardasil and Cervix against cervical cancer and HBS Ag Vaccine against hepatocellular carcinoma. If the researchers to design appropriate vaccines against H. pylori results in success, we can be hopeful to protect people against stomach cancer by vaccination in the future. The cancer prophylactic vaccines, in fact, protect the body against a specific cause of cancer not against cancer which emerged due to other reasons. In the case of cervical cancer, a prophylactic vaccine can immunize the body against papillomavirus infection, which if left untreated can cause subsequent cancer. About the hepatocellular carcinoma, the scenario is the same. The second type of cancer vaccine is therapeutic vaccines, which are given to patients who have already been diagnosed with cancer. Tumor cell, Peptides, Anti-idiotypic vaccines, DNA Vaccines and dendritic cell-based vaccine are different approaches in this category. There are some clinically available examples of cancer therapeutic vaccines, including OncoVax, Sipuleucel-T, and CimaVaxEGF. Although cancer vaccines are new in the treatment setting of cancer, maybe they will be the future of cancer treatments.

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    Toxicity of perfluorooctanoic acid: Implications for health risks

    On 8th May 2017, journal club meeting, the topic “Toxicity of perfluorooctanoic acid: Implications for health risks.” was discussed. As an emerging persistent organic pollutant (POP), perfluorooctanoate (PFOA) is one of the most abundant perfluorinated compounds (PFCs) in the environment. This molecular mechanisms and signaling pathways of PFOA-induced toxicity in animals and humans as well as their implications for health risks in humans were described. Traditional PFOA-induced signal pathways such as peroxisome proliferating receptor alpha (PPARα), constitutive androstane receptor (CAR), farnesoid X receptor (FXR), and pregnane-X receptor (PXR) may not be important for PFOA-induced health effects on humans. Instead, pathways, including p53/mitochondrial, nuclear lipid hyperaccumulation, phosphatidylinositol 3-kinase-serine/threonine protein kinase (PI3K-AKT), and tumor necrosis factor-α/nuclear factor κB (TNF-α/NF-κB) play roles for PFOA-induced health risks in humans. Both in vivo and in vitro studies are needed to better understand the PFOA-induced toxicity mechanisms as well as the associated health risk in humans.